Detailed Information

Cited 23 time in webofscience Cited 25 time in scopus
Metadata Downloads

Photodynamic Anticancer Activities of Multifunctional Cobalt Ferrite Nanoparticles in Various Cancer Cells

Authors
Park, Bong JooChoi, Kyong-HoonNam, Ki ChangAli, AnserMin, Jee EunSon, HyungbinUhm, Han S.Kim, Ho-JoongJung, Jin-SeungChoi, Eun Ha
Issue Date
Feb-2015
Publisher
AMER SCIENTIFIC PUBLISHERS
Keywords
Cobalt Ferrite Nanoparticles; Hematoporphyrin; Folic Acid; Magnetic Resonance Imaging; Biocompatibility; Photodynamic Anti-Cancer Activity
Citation
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v.11, no.2, pp 226 - 235
Pages
10
Journal Title
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume
11
Number
2
Start Page
226
End Page
235
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9879
DOI
10.1166/jbn.2015.2031
ISSN
1550-7033
1550-7041
Abstract
To develop novel multifunctional magnetic nanoparticles (MNPs) with good magnetic properties, biocompatibility, and anticancer activities by photodynamic therapy (PDT), we synthesized multifunctional cobalt ferrite (CoFe2O4) nanoparticles (CoFe2O4-HPs-FAs) functionalized by coating them with hematoporphyrin (HP) for introducing photo-functionality and by conjugating with folic acid (FA) for targeting cancer cells. We evaluated the activities of the CoFe2O4-HPs-FAs by checking magnetic resonance imaging (MRI) in vitro, its biocompatibility, and photodynamic anticancer activities on FA receptor (FR)-positive and FR-negative cancer cell lines, Hela, KB, MCF-7, and PC-3 cells, to use for clinical applications. In this study, we have demonstrated that the CoFe2O4-HPs-FAs have good MRI and biocompatibility with non-cytotoxicity, and remarkable photodynamic anticancer activities at very low concentrations regardless of cell types. Particularly, the photo-killing abilities in 3.13 mu g/mL of CoFe2O4-HPs-FAs were measured to be 91.8% (p < 0.002) for Hela, 94.5% (p < 0.007) for KB, 79.1% (p < 0.003) for MCF-7, and 71.3% (p < 0.006) for PC-3. The photodynamic anticancer activities in 6.25 and 12.5 mu g/mL of CoFe2O4-HPs-FAs were measured to be over 95% (p < 0.004) to almost 100% regardless of cell types. The newly developed multifunctional CoFe2O4-HPs-FAs are effective for PDT and have potential as therapeutic agents for MRI-based PDT, because they have a high saturation value of magnetization and superparamagnetism.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of ICT Engineering > School of Integrative Engineering > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Son, Hyungbin photo

Son, Hyungbin
창의ICT공과대학 (융합공학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE