Improved oral absorption of dutasteride via Soluplus (R)-based supersaturable self-emulsifying drug delivery system (S-SEDDS)

Abstract

A novel supersaturable self-emulsifying drug delivery system (S-SEDDS) was formulated to improve the oral absorption of dutasteride (DTS), a 5 alpha-reductase inhibitor that is poorly water-soluble. A supersaturable system was prepared by employing Soluplus (R) (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer) as a precipitation inhibitor with a conventional SEDDS vehicle consisted of Capryol (TM) 90, Cremophor (R) EL and Transcutol (R) HP (DTS:SEDDS vehicle: Soluplus (R) = 1.0:67.6:10.0 w/v/w). In an in vitro dissolution test in a non-sink condition, the drug dissolution rate from SEDDS was rapidly increased to 72% for an initial period of 5 min, but underwent rapid drug precipitation within 2 h, decreasing the amount of drug dissolved to one-seventh of its original amount. On the other hand, S-SEDDS resulted in a slower crystallization of DTS by virtue of a precipitation inhibitor, maintaining a 3 times greater dissolution rate after 2 h compared to SEDDS. In an in vivo pharmacokinetic study in rats, the S-SEDDS formulation exhibited 3.9-fold greater area-under-curve value than that of the drug suspension and 1.3-fold greater than that of SEDDS. The maximum plasma concentration of S-SEDDS was 5.6- and 2.0-fold higher compared to drug suspension and SEDDS, respectively. The results of this study suggest that the novel supersaturable system may be a promising tool for improving the physicochemical property and oral absorption of the 5 alpha-reductase inhibitor. (C) 2014 Elsevier B.V. All rights reserved.