Synergistic anticancer activity of combined histone deacetylase and proteasomal inhibitor-loaded zein nanoparticles in metastatic prostate cancers
- Authors
- Thapa, Raj Kumar; Hanh Thuy Nguyen; Jeong, Jee-Heon; Shin, Beom Soo; Ku, Sae Kwang; Choi, Han-Gon; Yong, Chul Soon; Kim, Jong Oh
- Issue Date
- Apr-2017
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Zein nanoparticles; Bortezomib; Vorinostat; Prostate cancer
- Citation
- NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, v.13, no.3, pp.885 - 896
- Indexed
- SCIE
SCOPUS
- Journal Title
- NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
- Volume
- 13
- Number
- 3
- Start Page
- 885
- End Page
- 896
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/10037
- DOI
- 10.1016/j.nano.2016.12.010
- ISSN
- 1549-9634
- Abstract
- The development of resistance and subsequent metastasis makes prostate cancer a leading cause of cancer-related death among men. Hence, nanoparticle-based combination chemotherapeutics could be a viable treatment strategy. Weaimed to prepare vorinostat (Vor) and bortezomib (Bor) combination-loaded zein nanoparticles (ZNP, ZNP/VB) for treating metastatic prostate cancers. Our results revealed the successful preparation of ZNP/VB with a small particle size (similar to 160 nm) and polydispersity index (similar to 0.20). Importantly, controlled and pH-dependent drug release profiles were observed. ZNP/VB exhibited high uptake in different prostate cancer cells and, thereby, exhibited higher cytotoxicity and apoptosis. Additionally, the enhanced anti-migration effect of and induction of pro-apoptotic proteins by ZNP/VB suggest its potential effectiveness in cancer treatment. ZNP/VB showed enhanced in vivo antitumor effects compared to that observed for each free drug and their combination, with minimal toxicity. Taken together, ZNP/VB could be a potential formulation for the effective treatment of metastatic prostate cancers. (C) 2016 Elsevier Inc. All rights reserved.
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