Host Cell Nuclear Localization of Shigella flexneri Effector OspF Is Facilitated by SUMOylationopen access
- Authors
- Jo, Kyungmin; Kim, Eun Jin; Yu, Hyun Jin; Yun, Cheol-Heui; Kim, Dong Wook
- Issue Date
- Mar-2017
- Publisher
- KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
- Keywords
- Shigella flexneri; effector; OspF; SUMO; nuclear localization
- Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.27, no.3, pp.610 - 615
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- Volume
- 27
- Number
- 3
- Start Page
- 610
- End Page
- 615
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/10110
- DOI
- 10.4014/jmb.1611.11066
- ISSN
- 1017-7825
- Abstract
- When Shigella infect host cells, various effecter molecules are delivered into the cytoplasm of the host cell through the type III secretion system (TTSS) to facilitate their invasion process and control the host immune responses. Among these effectors, the S. flexneri effector OspF dephosphorylates mitogen- activated protein kinases and translocates itself to the nucleus, thus preventing histone H3 modification to regulate expression of proinflammatory cytokines. Despite the critical role of OspF, the mechanism by which it localizes in the nucleus has remained to be elucidated. In the present study, we identified a potential small ubiquitinrelated modifier (SUMO) modification site within OspF and we demonstrated that Shigella TTSS effector OspF is conjugated with SUMO in the host cell and this modification mediates the nuclear translocation of OspF. Our results show a bacterial virulence factor can exploit host post-translational machinery to execute its intracellular trafficking.
- Files in This Item
-
Go to Link
- Appears in
Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/10110)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.