A Perspective on the Development of c-Jun N-terminal Kinase Inhibitors as Therapeutics for Alzheimer's Disease: Investigating Structure through Docking Studies
- Authors
- Cho, Hyunwook; Hah, Jung-Mi
- Issue Date
- Oct-2021
- Publisher
- MDPI
- Keywords
- Alzheimer' s disease; c-Jun N-terminal kinase; small-molecule protein kinase inhibitor; JNK3; selectivity
- Citation
- BIOMEDICINES, v.9, no.10
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMEDICINES
- Volume
- 9
- Number
- 10
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/108185
- DOI
- 10.3390/biomedicines9101431
- ISSN
- 2227-9059
- Abstract
- c-Jun N-terminal kinase (JNK) plays an important role in cell death caused by various stimuli. Because the isoform JNK3 is mainly expressed in the brain, it is believed to play a pivotal role in various neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), which still lack plausible therapeutics. To develop a novel and selective JNK3 inhibitor, we conducted a decadal review (2011 to 2021) of published articles on JNK inhibitors, particularly those focusing on a structural perspective and docking insights. We observed the structures of three isoforms of JNK, namely holo-proteins and co-crystal structures, with JNK3 inhibitors and summarized the significant structural aspects of selective JNK3 inhibitors as AD therapeutics.</p>
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Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
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