Microwave-Assisted Biosynthesized Gold Nanoparticles Using Saussurea obvallata: Biocompatibility and Antioxidant Activity Assessment

Abstract

Nanoparticles play a significant role in the development of pharmaceuticals. In the present study, gold nanoparticles (AuNPs) were synthesized using the microwave irradiation method and evaluated their cytocompatibility and antioxidant properties. Saussurea obvallata plant extract was used as a reducing agent to prepare AuNPs. The UV-visible spectra confirmed the formation of AuNPs with the surface plasmon resonance peak at 530 nm. Fourier transform infrared spectroscopy demonstrates that AuNPs were blended with different functional groups, including hydroxyl, amine, and alkyl halide. The scanning electron microscopy and transmission electron microscopy results indicate that AuNPs are spherical in size. The XRD analysis provides evidence for the existence of the AuNPs, which are coherent with standard AuNPs. The synthesized AuNPs showed excellent biocompatibility with IMR-32 cells up to 500 mu g/mL concentration. Furthermore, the biosynthesized AuNPs exhibited enhanced antioxidative activity at 1000 mu g/mL concentration. Hence, the developed AuNPs would have a potential biological application in the medical field.