Controllable Nitric Oxide Storage and Release in Cu-BTC: Crystallographic Insights and Bioactivityopen access
- Authors
- Lee, Do Nam; Kim, Yeong Rim; Yang, Sohyeon; Ngoc Minh Tran; Park, Bong Joo; Lee, Su Jung; Kim, Youngmee; Yoo, Hyojong; Kim, Sung-Jin; Shin, Jae Ho
- Issue Date
- Aug-2022
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- nitric oxide; drug delivery; MOFs; antibacterial activity
- Citation
- International Journal of Molecular Sciences, v.23, no.16, pp 1 - 15
- Pages
- 15
- Indexed
- SCIE
SCOPUS
- Journal Title
- International Journal of Molecular Sciences
- Volume
- 23
- Number
- 16
- Start Page
- 1
- End Page
- 15
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/112723
- DOI
- 10.3390/ijms23169098
- ISSN
- 1661-6596
1422-0067
- Abstract
- Crystalline metal-organic frameworks (MOFs) are extensively used in areas such as gas storage and small-molecule drug delivery. Although Cu-BTC (1, MOF-199, BTC: benzene-1,3,5-tricarboxylate) has versatile applications, its NO storage and release characteristics are not amenable to therapeutic usage. In this work, micro-sized Cu-BTC was prepared solvothermally and then processed by ball-milling to prepare nano-sized Cu-BTC (2). The NO storage and release properties of the micro- and nano-sized Cu-BTC MOFs were morphology dependent. Control of the hydration degree and morphology of the NO delivery vehicle improved the NO release characteristics significantly. In particular, the nano-sized NO-loaded Cu-BTC (NO subset of nano-Cu-BTC, 4) released NO at 1.81 mu mol center dot mg(-1) in 1.2 h in PBS, which meets the requirements for clinical usage. The solid-state structural formula of NO subset of Cu-BTC was successfully determined to be [CuC6H2O5]center dot(NO)(0.167) through single-crystal X-ray diffraction, suggesting no structural changes in Cu-BTC upon the intercalation of 0.167 equivalents of NO within the pores of Cu-BTC after NO loading. The structure of Cu-BTC was also stably maintained after NO release. NO subset of Cu-BTC exhibited significant antibacterial activity against six bacterial strains, including Gram-negative and positive bacteria. NO subset of Cu-BTC could be utilized as a hybrid NO donor to explore the synergistic effects of the known antibacterial properties of Cu-BTC.
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