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Stress-related cognitive style is related to volumetric change of the hippocampus and FK506 binding protein 5 polymorphism in post-traumatic stress disorder

Authors
Yun, Je-YeonJin, Min JinKim, SungkeanLee, Seung-Hwan
Issue Date
May-2022
Publisher
Cambridge University Press
Keywords
FK506 binding protein 5 gene (FKBP5); hippocampus; post-traumatic stress disorder; stress-related cognitive style
Citation
Psychological Medicine, v.52, no.7, pp 1243 - 1254
Pages
12
Indexed
SCIE
SSCI
SCOPUS
Journal Title
Psychological Medicine
Volume
52
Number
7
Start Page
1243
End Page
1254
URI
https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/113525
DOI
10.1017/S0033291720002949
ISSN
0033-2917
1469-8978
Abstract
Background Patients with post-traumatic stress disorder (PTSD) show a different stress-related cognitive style compared with healthy controls (HC). The FK506 binding protein 5 gene (FKBP5), one of the PTSD known risk factors, is involved in the stress response through the hypothalamic-pituitary-adrenal axis and brain volumetric alterations. The present study aimed to uncover the neural correlates of stress-related cognitive styles through the analysis of the regional brain volumes and FKBP5 genotype in patients with PTSD compared with HC. Methods In this study, 51 patients with PTSD and 94 HC were assessed for stress-related cognitive styles, PTSD symptoms severity, and genotype of FKBP5 single nucleotide polymorphisms, and underwent T1-weighted structural magnetic resonance imaging. Diagnosis-by-genotype interaction for regional brain volumes was examined in 16 brain regions of interest. Results Patients with PTSD showed significantly higher levels of catastrophizing, ruminative response, and repression, and reduced distress aversion and positive reappraisal compared with HC (p ˂ 0.001). Significant diagnosis-by-genotype interactions for regional brain volumes were observed for bilateral hippocampi and left frontal operculum. A significant positive correlation between the severity of the repression and left hippocampal volume was found in a subgroup of patients with PTSD with FKBP5 rs3800373 (AA genotype) or rs1360780 (CC genotype). Conclusions The present study showed the influences of FKBP5 genotype on the distorted cognitive styles in PTSD by measuring the volumetric alteration of hippocampal regions, providing a possible role of the hippocampus and left frontal operculum as significant neurobiological correlates of PTSD.
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