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In Vitro Hepatic Steatosis Model based on Gut-liver-on-a-chip

Authors
Jeon, Joong-wonLee, Seung HwanKim, DonghyunSung, Jong Hwan
Issue Date
May-2021
Publisher
American Chemical Society
Keywords
fatty liver disease; gut–liver-on-a-chip; hepatic steatosis; multi-organ-on-a-chip; organ-on-a-chip
Citation
Biotechnology Progress, v.37, no.3, pp 1 - 13
Pages
13
Indexed
SCIE
SCOPUS
Journal Title
Biotechnology Progress
Volume
37
Number
3
Start Page
1
End Page
13
URI
https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/113651
DOI
10.1002/btpr.3121
ISSN
8756-7938
1520-6033
Abstract
Hepatic steatosis, also known as fatty liver disease, occurs due to abnormal lipid accumulation in the liver. It has been known that gut absorption also plays an important role in the mechanism underlying hepatic steatosis. Conventional in vitro cell culture models have limitations in recapitulating the mechanisms of hepatic steatosis because it does not include the gut absorption process. Previously, we reported development of a microfluidic gut–liver chip that can recapitulate the gut absorption of fatty acids and subsequent lipid accumulation in liver cells. In this study, we performed a series of experiments to verify that our gut–liver chip reproduces various aspects of hepatic steatosis. The absorption of fatty acids was evaluated under various culture conditions. The anti-steatotic effect of turofexorate isopropyl (XL-335) and metformin was tested, and both drugs showed different action mechanisms. In addition, the oxidative stress induced by lipid absorption was evaluated. Our results demonstrate the potential of the gut–liver chip for use as a novel, physiologically realistic in vitro model to study fatty liver disease. © 2021 American Institute of Chemical Engineers
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LEE, SEUNG HWAN
ERICA 공학대학 (DEPARTMENT OF BIONANO ENGINEERING)
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