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Trapping of Methylglyoxal by Sieboldin from Malus baccata L. and Identification of Sieboldin-Methylglyoxal Adducts Forms
- Authors
- Kim, Ji Hoon; Zhang, Kaixuan; Lee, Juhee; Gao, En Mei; Lee, Yun Jung; Son, Rak Ho; Syed, Ahmed Shah; Kim, Chul Young
- Issue Date
- Dec-2021
- Publisher
- 한국생약학회
- Keywords
- Malus baccata L.; Methylglyoxal trapping; Sieboldin
- Citation
- Natural Product Sciences, v.27, no.4, pp 245 - 250
- Pages
- 6
- Indexed
- SCOPUS
KCI
- Journal Title
- Natural Product Sciences
- Volume
- 27
- Number
- 4
- Start Page
- 245
- End Page
- 250
- ISSN
- 1226-3907
- Abstract
- The methylglyoxal (MGO) trapping constituents from Malus baccata L. were investigated using incubation of MGO and crude extract under physiological conditions followed by HPLC analysis. The peak areas of MGO trapping compounds decreased, and their chemical structures were identified by HPLC-ESI/MS. Sieboldin was identified as a major active molecule representing MGO-trapping activity of the crude extract. After reaction of sieboldin and MGO, remaining MGO was calculated by microplate assay method using imine (Schiff base) formation of 2,4-dinitrophenylhydrazine (DNPH) and aldehyde group. After 4 h incubation, sieboldin trapped over 43.8% MGO at a concentration of 0.33 mM and showed MGO scavenging activity with an RC
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Related Researcher
- Kim, Chul Young
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)