Integrated molecular characterization of adult soft tissue sarcoma for therapeutic targetsopen access
- Authors
- Kim, Jihyun; Kim, June Hyuk; Kang, Hyun Guy; Park, Seog Yun; Yu, Jung Yeon; Lee, Eun Young; Oh, Sung Eun; Yun, Tak; Park, Charny; Cho, Soo Young; You, Hye Jin
- Issue Date
- Dec-2018
- Publisher
- BioMed Central
- Keywords
- CDK4 and RB1; Complex karyotype sarcoma; Molecular characterization; PDGFRA
- Citation
- BMC Medical Genetics, v.19, pp 1 - 11
- Pages
- 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- BMC Medical Genetics
- Volume
- 19
- Start Page
- 1
- End Page
- 11
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/114381
- DOI
- 10.1186/s12881-018-0722-6
- ISSN
- 1471-2350
- Abstract
- Background: Several studies have investigated the molecular drivers and therapeutic targets in adult soft tissue sarcomas. However, such studies are limited by the genomic heterogeneity and rarity of sarcomas, particularly in those with complex and unbalanced karyotypes. Additional biomarkers are needed across sarcoma types to improve therapeutic strategies. To investigate the molecular characteristics of complex karyotype sarcomas (CKSs) for therapeutic targets, we performed genomic profiling. Results: The mutational landscape showed that TP53, ATRX, and PTEN genes were highly mutated. CKS samples were categorized into three groups based on copy number variations that were associated with CDK4 and RB1 signatures. Integrated analysis of genomic and transcriptomic data revealed several pathways related to PDGFR, which could be a strategic target for anti-sarcoma therapy. Conclusions: This study provides a detailed molecular classification of CKSs and proposes several therapeutic targets. Targeted or combinational therapies for treating CKS should be considered before chemotherapy. © 2018 The Author(s).
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