Photocatalytic intermolecular bromonitroalkylation of styrenes: synthesis of cyclopropylamine derivatives and their evaluation as LSD1 inhibitorsopen access
- Authors
- Kim, Darong; Jeon, Hui-Jeon; Kwak, Yoonna; Lee, Sun Joo; Nam, Tae-Gyu; Yu, Ji Hoon; An, Hongchan; Hong, Ki Bum
- Issue Date
- Jan-2024
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- RSC ADVANCES, v.14, no.2, pp 831 - 835
- Pages
- 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- RSC ADVANCES
- Volume
- 14
- Number
- 2
- Start Page
- 831
- End Page
- 835
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/117694
- DOI
- 10.1039/d3ra07830b
- ISSN
- 2046-2069
2046-2069
- Abstract
- A mild and efficient method for photoredox-catalyzed bromonitroalkylation of alkenes is described herein. In this reaction, bromonitromethane serves as a source of both nitroalkyl and bromine for direct and regioselective formation of C-Br and C-C bonds from alkenes, and additional cyclization provides C-C bonds to the cyclopropylamine core as an LSD1 inhibitor. A mild and efficient method for photoredox-catalyzed bromonitroalkylation of alkenes is described herein.
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Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
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