Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Evaluation of the inhibitory effect of Gynostemma pentaphyllum extracts on CYP450 enzyme activities using LC-MS/MSopen access
- Issue Date
- Sep-2023
- Publisher
- 사단법인 한국질량분석학회
- Keywords
- cytochrome P450; Gynostemma pentaphyllum; herb-drug interaction; LC-MS/MS
- Citation
- Mass Spectrometry Letters, v.14, no.3, pp 116 - 119
- Pages
- 4
- Indexed
- SCOPUS
ESCI
KCI
- Journal Title
- Mass Spectrometry Letters
- Volume
- 14
- Number
- 3
- Start Page
- 116
- End Page
- 119
- ISSN
- 2233-4203
2093-8950
- Abstract
- Gynostemma pentaphyllum (Thunb.) Makino extract, a natural product with a history of traditional use, has gained attention for its potential health benefits. This study aimed to investigate its effects on key cytochrome P450 (CYP) enzymes using LC-MS/MS. Human liver microsomes and cDNA-expressed CYP2C8, CYP2C9, CYP2C19, and CYP3A4 supersomes were employed. Enzyme activity was assessed based on the formation of CYP-specific marker metabolites. The resulting data showed that the extract exhibited inhibitory effects on CYP2C8, CYP2C9, CYP2C19, and CYP3A4. Thus, G. pentaphyllum extract may influence the pharmacokinetics of drugs metabolized by CYP2C8, CYP2C9, CYP2C19, and CYP3A4. These find-ings emphasize the importance of considering potential herb-drug interactions when incorporating this extract into therapeutic regimens or dietary supplements. © 2023, Korean Society for Mass Spectrometry. All rights reserved.
- Files in This Item
- Go to Link
- Appears in
Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Yoo, Hye Hyun
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)