SABRE hyperpolarization of nicotinamide derivatives and their molecular dynamics properties
- Authors
- Luu, Quy Son; Nguyen, Quynh Thi; Manh, Hung Ngo; Yun, Seokki; Kim, Jiwon; Do, Uyen Thi; Jeong, Keunhong; Lee, Sang Uck; Lee, Youngbok
- Issue Date
- Feb-2024
- Publisher
- Royal Society of Chemistry
- Citation
- Analyst, v.149, no.4, pp 1068 - 1073
- Pages
- 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- Analyst
- Volume
- 149
- Number
- 4
- Start Page
- 1068
- End Page
- 1073
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/118199
- DOI
- 10.1039/d3an02053c
- ISSN
- 0003-2654
1364-5528
- Abstract
- Signal amplification by reversible exchange hyperpolarization explores the chemical structure and kinetic properties of nicotinamide derivatives. N-Benzyl nicotinamide and nicotinic acid hydrazide compounds display relatively fast dissociation rates of approximately 7-8 s-1 and long proton T1 relaxation times of 5-20 s, respectively. Consequently, these substrates exhibit remarkable signal enhancements, reaching approximately 175 and 102 fold, respectively, underscoring the efficacy of the hyperpolarization technique in elucidating the behavior of these compounds. This research highlights the high signal enhancement of nicotinic acid hydrazide and N-benzyl nicotinamide through SABRE hyperpolarization, which was explained by ligand dissociation rate and T1 relaxation time.
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- Appears in
Collections - COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY > DEPARTMENT OF CHEMICAL AND MOLECULAR ENGINEERING > 1. Journal Articles
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