Polyvinyl Alcohol Cryogels for Acoustic Characterization of Phase-Change Contrast Agents
- Authors
- Durham, Phillip G.; Kim, Jinwook; Eltz, Katherine M.; Caskey, Charles F.; Dayton, Paul A.
- Issue Date
- May-2022
- Publisher
- Elsevier BV
- Keywords
- Nanodroplets; Phase-change contrast agent; Polyvinyl alcohol cryogel
- Citation
- Ultrasound in Medicine and Biology, v.48, no.5, pp 954 - 960
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- Ultrasound in Medicine and Biology
- Volume
- 48
- Number
- 5
- Start Page
- 954
- End Page
- 960
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/118548
- DOI
- 10.1016/j.ultrasmedbio.2022.01.007
- ISSN
- 0301-5629
1879-291X
- Abstract
- Phase-change contrast agents (PCCAs) consisting of lipid-encapsulated low-boiling-point perfluorocarbons can be used in conjunction with ultrasound for diagnostic and therapeutic applications. One benefit of PCCAs is site-specific activation, whereby the liquid core is acoustically vaporized into a bubble detectable via ultrasound imaging. For further evaluation of PCCAs in a variety of applications, it is useful to disperse these nanodroplets into an acoustically compatible stationary matrix. However, many traditional phantom preparations require heating, which causes premature thermal activation of low-boiling-point PCCAs. Polyvinyl alcohol (PVA) cryogels do not require heat to set. Here we propose a simple method for the incorporation of the low-boiling-point PCCAs using octafluoropropane (OFP) and decafluorobutane (DFB) into PVA cryogels for a variety of acoustic characterization applications. We determined the utility of the phantoms by activating droplets with a focused transducer, visualizing the lesions with ultrasound imaging. At 1 MHz, droplet activation was consistently observed at 2.0 and 4.0 MPa for OFP and DFB, respectively. © 2022 World Federation for Ultrasound in Medicine & Biology
- Files in This Item
-
- Appears in
Collections - COLLEGE OF ENGINEERING SCIENCES > DEPARTMENT OF MECHANICAL ENGINEERING > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.