Therapeutic potential of ginseng leaf extract in inhibiting mast cell-mediated allergic inflammation and atopic dermatitis-like skin inflammation in DNCB-treated mice
DC Field | Value | Language |
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dc.contributor.author | Oh, Jung-Mi | - |
dc.contributor.author | Yoon, HyunHo | - |
dc.contributor.author | Joo, Jae-Yeol | - |
dc.contributor.author | Im, Wan-Taek | - |
dc.contributor.author | Chun, Sungkun | - |
dc.date.accessioned | 2024-05-29T02:00:30Z | - |
dc.date.available | 2024-05-29T02:00:30Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 1663-9812 | - |
dc.identifier.issn | 1663-9812 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/119136 | - |
dc.description.abstract | Ginseng leaves are known to contain high concentrations of bioactive compounds, such as ginsenosides, and have potential as a treatment for various conditions, including fungal infections, cancer, obesity, oxidative stress, and age-related diseases. This study assessed the impact of ginseng leaf extract (GLE) on mast cell-mediated allergic inflammation and atopic dermatitis (AD) in DNCB-treated mice. GLE reduced skin thickness and lymph node nodules and suppressed the expression and secretion of histamine and pro-inflammatory cytokines. It also significantly lowered the production of inflammatory response mediators including ROS, leukotriene C4 (LTC4), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS). GLE inhibited the phosphorylation of MAPKs (ERK, P38, JNK) and the activation of NF-κB, which are both linked to inflammatory cytokine expression. We demonstrated that GLE’s inhibitory effect on mast cell-mediated allergic inflammation is due to the blockade of the NF-κB and inflammasome pathways. Our findings suggest that GLE can be an effective therapeutic agent for mast-cell mediated and allergic inflammatory conditions. | - |
dc.format.extent | 20 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Therapeutic potential of ginseng leaf extract in inhibiting mast cell-mediated allergic inflammation and atopic dermatitis-like skin inflammation in DNCB-treated mice | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3389/fphar.2024.1403285 | - |
dc.identifier.scopusid | 2-s2.0-85195090708 | - |
dc.identifier.wosid | 001238205200001 | - |
dc.identifier.bibliographicCitation | Frontiers in Pharmacology, v.15, no.15, pp 1 - 20 | - |
dc.citation.title | Frontiers in Pharmacology | - |
dc.citation.volume | 15 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 20 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | RED GINSENG | - |
dc.subject.keywordPlus | NLRP3 INFLAMMASOME | - |
dc.subject.keywordPlus | PANAX-GINSENG | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | IGE | - |
dc.subject.keywordPlus | PROSTAGLANDIN-E2 | - |
dc.subject.keywordPlus | GINSENOSIDES | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordAuthor | degranulation | - |
dc.subject.keywordAuthor | ginseng leaf extract | - |
dc.subject.keywordAuthor | inflammasome | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordAuthor | NF-κB | - |
dc.subject.keywordAuthor | pro-inflammatory cytokines | - |
dc.identifier.url | https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1403285/full | - |
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