Therapeutic potential of ginseng leaf extract in inhibiting mast cell-mediated allergic inflammation and atopic dermatitis-like skin inflammation in DNCB-treated miceopen access
- Authors
- Oh, Jung-Mi; Yoon, HyunHo; Joo, Jae-Yeol; Im, Wan-Taek; Chun, Sungkun
- Issue Date
- May-2024
- Publisher
- Frontiers Media S.A.
- Keywords
- anti-inflammatory; degranulation; ginseng leaf extract; inflammasome; MAPK; NF-κB; pro-inflammatory cytokines
- Citation
- Frontiers in Pharmacology, v.15, no.15, pp 1 - 20
- Pages
- 20
- Indexed
- SCIE
SCOPUS
- Journal Title
- Frontiers in Pharmacology
- Volume
- 15
- Number
- 15
- Start Page
- 1
- End Page
- 20
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/119136
- DOI
- 10.3389/fphar.2024.1403285
- ISSN
- 1663-9812
1663-9812
- Abstract
- Ginseng leaves are known to contain high concentrations of bioactive compounds, such as ginsenosides, and have potential as a treatment for various conditions, including fungal infections, cancer, obesity, oxidative stress, and age-related diseases. This study assessed the impact of ginseng leaf extract (GLE) on mast cell-mediated allergic inflammation and atopic dermatitis (AD) in DNCB-treated mice. GLE reduced skin thickness and lymph node nodules and suppressed the expression and secretion of histamine and pro-inflammatory cytokines. It also significantly lowered the production of inflammatory response mediators including ROS, leukotriene C4 (LTC4), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS). GLE inhibited the phosphorylation of MAPKs (ERK, P38, JNK) and the activation of NF-κB, which are both linked to inflammatory cytokine expression. We demonstrated that GLE’s inhibitory effect on mast cell-mediated allergic inflammation is due to the blockade of the NF-κB and inflammasome pathways. Our findings suggest that GLE can be an effective therapeutic agent for mast-cell mediated and allergic inflammatory conditions.
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