Comparison of two self-nanoemulsifying drug delivery systems using different solidification techniques for enhanced solubility and oral bioavailability of poorly water-soluble celecoxib
DC Field | Value | Language |
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dc.contributor.author | Woo, Mi Ran | - |
dc.contributor.author | Woo, Sanghyun | - |
dc.contributor.author | Bak, Young-Woo | - |
dc.contributor.author | Cheon, Seunghyun | - |
dc.contributor.author | Kim, Jung Suk | - |
dc.contributor.author | Ji, Sang Hun | - |
dc.contributor.author | Park, Seonghyeon | - |
dc.contributor.author | Kim, Jong Oh | - |
dc.contributor.author | Jin, Sung Giu | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.date.accessioned | 2024-07-22T08:00:51Z | - |
dc.date.available | 2024-07-22T08:00:51Z | - |
dc.date.issued | 2024-09 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.issn | 1873-4367 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/120105 | - |
dc.description.abstract | In this study, we aimed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) and a solid selfnanoemulsifying granule system (S-SNEGS) to enhance the solubility and oral bioavailability of celecoxib. This process involved the preparation of a liquid SNEDDS (L-SNEDDS) and its subsequent solidification into a SSNEDDS and a S-SNEGS. The L-SNEDDS consisted of celecoxib (drug), Captex (R) 355 (Captex; oil), Tween (R) 80 (Tween 80; surfactant) and D- alpha-Tocopherol polyethylene glycol 1000 succinate (TPGS; cosurfactant) in a weight ratio of 3.5:25:60:15 to produce the smallest nanoemulsion droplet size. The S-SNEDDS and S-SNEGS were prepared with L-SNEDDS/Ca-silicate/Avicel PH 101 in a weight ratio of 103.5:50:0 using a spray dryer and 103.5:50:100 using a fluid bed granulator, respectively. We compared the two novel developed systems and celecoxib powder based on their solubility, dissolution rate, physicochemical properties, flow properties and oral bioavailability in rats. S-SNEGS showed a significant improvement in solubility and dissolution rate compared to S-SNEDDS and celecoxib powder. Both systems had been converted from crystalline drug to amorphous form. Furthermore, S-SNEGS exhibited a significantly reduced angle of repose, compressibility index and Hausner ratio than S-SNEDDS, suggesting that S-SNEGS was significantly superior in flow properties. Compared to S-SNEDDS and celecoxib powder, S-SNEGS increased the oral bioavailability (AUC value) in rats by 1.3 and 4.5-fold, respectively. Therefore, S-SNEGS wolud be recommended as a solid self-nanoemulsifying system suitable for poorly water-soluble celecoxib. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Comparison of two self-nanoemulsifying drug delivery systems using different solidification techniques for enhanced solubility and oral bioavailability of poorly water-soluble celecoxib | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.colsurfb.2024.114044 | - |
dc.identifier.scopusid | 2-s2.0-85197305542 | - |
dc.identifier.wosid | 001265630600001 | - |
dc.identifier.bibliographicCitation | Colloids and Surfaces B: Biointerfaces, v.241, pp 1 - 12 | - |
dc.citation.title | Colloids and Surfaces B: Biointerfaces | - |
dc.citation.volume | 241 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.type.docType | ARTICLE | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | DISSOLUTION | - |
dc.subject.keywordAuthor | Celecoxib | - |
dc.subject.keywordAuthor | Solid self-nanoemulsifying drug delivery sys | - |
dc.subject.keywordAuthor | tem | - |
dc.subject.keywordAuthor | Solid self-nanoemulsifying granule system | - |
dc.subject.keywordAuthor | Solubility | - |
dc.subject.keywordAuthor | Flow properties | - |
dc.subject.keywordAuthor | Oral bioavailability | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0927776524003035?pes=vor | - |
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