Comparison of two self-nanoemulsifying drug delivery systems using different solidification techniques for enhanced solubility and oral bioavailability of poorly water-soluble celecoxib
- Authors
- Woo, Mi Ran; Woo, Sanghyun; Bak, Young-Woo; Cheon, Seunghyun; Kim, Jung Suk; Ji, Sang Hun; Park, Seonghyeon; Kim, Jong Oh; Jin, Sung Giu; Choi, Han-Gon
- Issue Date
- Sep-2024
- Publisher
- Elsevier BV
- Keywords
- Celecoxib; Solid self-nanoemulsifying drug delivery sys; tem; Solid self-nanoemulsifying granule system; Solubility; Flow properties; Oral bioavailability
- Citation
- Colloids and Surfaces B: Biointerfaces, v.241, pp 1 - 12
- Pages
- 12
- Indexed
- SCIE
SCOPUS
- Journal Title
- Colloids and Surfaces B: Biointerfaces
- Volume
- 241
- Start Page
- 1
- End Page
- 12
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/120105
- DOI
- 10.1016/j.colsurfb.2024.114044
- ISSN
- 0927-7765
1873-4367
- Abstract
- In this study, we aimed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) and a solid selfnanoemulsifying granule system (S-SNEGS) to enhance the solubility and oral bioavailability of celecoxib. This process involved the preparation of a liquid SNEDDS (L-SNEDDS) and its subsequent solidification into a SSNEDDS and a S-SNEGS. The L-SNEDDS consisted of celecoxib (drug), Captex (R) 355 (Captex; oil), Tween (R) 80 (Tween 80; surfactant) and D- alpha-Tocopherol polyethylene glycol 1000 succinate (TPGS; cosurfactant) in a weight ratio of 3.5:25:60:15 to produce the smallest nanoemulsion droplet size. The S-SNEDDS and S-SNEGS were prepared with L-SNEDDS/Ca-silicate/Avicel PH 101 in a weight ratio of 103.5:50:0 using a spray dryer and 103.5:50:100 using a fluid bed granulator, respectively. We compared the two novel developed systems and celecoxib powder based on their solubility, dissolution rate, physicochemical properties, flow properties and oral bioavailability in rats. S-SNEGS showed a significant improvement in solubility and dissolution rate compared to S-SNEDDS and celecoxib powder. Both systems had been converted from crystalline drug to amorphous form. Furthermore, S-SNEGS exhibited a significantly reduced angle of repose, compressibility index and Hausner ratio than S-SNEDDS, suggesting that S-SNEGS was significantly superior in flow properties. Compared to S-SNEDDS and celecoxib powder, S-SNEGS increased the oral bioavailability (AUC value) in rats by 1.3 and 4.5-fold, respectively. Therefore, S-SNEGS wolud be recommended as a solid self-nanoemulsifying system suitable for poorly water-soluble celecoxib.
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