Application of the Emerging Technologies in Toxicogenomics: An Overview

Abstract

Toxicogenomics is a rapidly developing area of research which combines the understanding of molecular and cellular regulation in response to interaction of chemical stressors. Moreover, the emergence of comprehensive research method covering genomic, proteomic, and metabonomics analysis including bioinformatics has further substantiated the field of toxicogenomics. Thus, evaluation of such integrated analysis, conversing from variety of experimental techniques, along with the resulting database can decipher the importantance of such techniques in toxicogenomics. In addition, recent integration of epigenetic study (DNA Methylation, histone modification, small and non coding RNAs) with toxicogenomics can pave the path to elucidate, highly reliable research results. The objective of the present review is to expand these understandings of toxicogenomics approach and validate the contribution of the developing research methods (genome, proteome, metabolites) to emphasize its importance in future toxicogenomics research.