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Solid-Phase Synthesis of 2-O-Methoxyethyl Oligonucleotides Using Dimeric Phosphoramidite Blocks
- Authors
- Yu, Gi Weon; Kang, Yong Han
- Issue Date
- Nov-2016
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Phosphoramidite; 2-O-Methoxyethyl oligonucleotide; Solid-phase synthesis; Dimer phosphoramidite block
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.37, no.11, pp.1754 - 1759
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 37
- Number
- 11
- Start Page
- 1754
- End Page
- 1759
- ISSN
- 0253-2964
- Abstract
- This research focused on the method of using dimeric phosphoramidite blocks to synthesize oligonucleotides for development as oligonucleotide drugs. A 16-mer oligonucleotide with the randomly selected sequence of C*C*T*C*G*C*T*C*T*C*G*C*C*C*G*C was synthesized using CC, GC, and TC dimers, a combination of monomers and dimers, or only monomers as building blocks. Using dimer blocks in this synthetic method provided a significant decrease in critical impurities that had similar properties to the main product, which was confirmed by LC-MS and HPLC analysis.
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