Pyridoanthrone-based chromo-fluorogenic amphiphiles for selective CN- detection and their bioimaging application
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kumar, Ashwani | - |
dc.contributor.author | Vanita, Vanita | - |
dc.contributor.author | Walia, Amandeep | - |
dc.contributor.author | Chae, Pil Seok | - |
dc.contributor.author | Kumar, Subodh | - |
dc.date.accessioned | 2021-06-22T09:07:52Z | - |
dc.date.available | 2021-06-22T09:07:52Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 0925-4005 | - |
dc.identifier.issn | 0925-4005 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/1295 | - |
dc.description.abstract | Cyanide anion (CN-) is one of the most hazardous chemicals for humans but is inevitably used in various purposes. In this study, we prepared fluorescent pyridoanthrone-based probes 1 and 3 with an N-octyl viologen pendant to detect this toxic anion. Among various anions, the presence of CN- only turned over a large fluorescence enhancement of these viologen probes, giving an LOD of 1 and 10 nM for probes 1 and 3, respectively. These probes also enabled for 'naked-eye detection' thanks to the generation of vivid pink color in the presence of this anion. Other probes (2, 4 and 5) with no N-octyl viologen pendant were also capable of selectively sensing CN-, but clearly inferior to probes 1 and 3 in terms of detection sensitivity. The sensitive and fast CN- detection was ascribed to the efficient addition reaction of each N-octyl viologen probe with CN-, leading to the generation of a highly fluorescent hydrolyzed product, isolated as a pyridoanthrone amine derivative. Due to the presence of hydrophobic and aromatic-aromatic interactions as well as H-bonding between probe molecules, the probes organized into self-assemblies with the positive surfaces in aqueous solution, allowing fast addition reactions between the probe and CN- to produce color and fluorescence emission. Probe 1 proved effective at detecting CN- content in HeLa cells and could be used as a solid state for inexpensive and convenient detection of CN-. The current system was fully studied by various analytical methods such as UV-vis, fluorescence, and H-1 NMR spectroscopy, DLS, FE-SEM images, TEM, DFT calculations, HRMS and X-ray crystallography. | - |
dc.format.extent | 15 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Pyridoanthrone-based chromo-fluorogenic amphiphiles for selective CN- detection and their bioimaging application | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.1016/j.snb.2019.127396 | - |
dc.identifier.scopusid | 2-s2.0-85075788006 | - |
dc.identifier.wosid | 000500702500110 | - |
dc.identifier.bibliographicCitation | Sensors and Actuators, B: Chemical, v.304, pp 1 - 15 | - |
dc.citation.title | Sensors and Actuators, B: Chemical | - |
dc.citation.volume | 304 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 15 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Electrochemistry | - |
dc.relation.journalResearchArea | Instruments & Instrumentation | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Electrochemistry | - |
dc.relation.journalWebOfScienceCategory | Instruments & Instrumentation | - |
dc.subject.keywordPlus | INDUCED EMISSION ENHANCEMENT | - |
dc.subject.keywordPlus | HYDROGEN-CYANIDE | - |
dc.subject.keywordPlus | FLUORESCENT SENSOR | - |
dc.subject.keywordPlus | RATIOMETRIC DETECTION | - |
dc.subject.keywordPlus | ELECTRON-TRANSFER | - |
dc.subject.keywordPlus | TRACE DETECTION | - |
dc.subject.keywordPlus | AQUEOUS-MEDIA | - |
dc.subject.keywordPlus | ANION | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | IONS | - |
dc.subject.keywordAuthor | Chromofluorogenic | - |
dc.subject.keywordAuthor | Pyridoanthrone-viologen amphiphiles | - |
dc.subject.keywordAuthor | CN- sensor | - |
dc.subject.keywordAuthor | Aqueous medium | - |
dc.subject.keywordAuthor | Live cell imaging | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0925400519315953?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.