Effective delivery of immunosuppressive drug molecules by silica coated iron oxide nanoparticles
- Authors
- Hwang, Jangsun; Lee, Eunwon; Kim, Jieun; Seo, Youngmin; Lee, Kwan Hong; Hong, Jong Wook; Gilad, Assaf A.; Park, Hansoo; Choi, Jonghoon
- Issue Date
- Jun-2016
- Publisher
- ELSEVIER
- Keywords
- Iron oxide nanoparticles; Mycophenolic acid; Immunosuppressive drug; Magnetic resonance imaging; Drug delivery
- Citation
- COLLOIDS AND SURFACES B-BIOINTERFACES, v.142, pp.290 - 296
- Indexed
- SCIE
SCOPUS
- Journal Title
- COLLOIDS AND SURFACES B-BIOINTERFACES
- Volume
- 142
- Start Page
- 290
- End Page
- 296
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/13578
- DOI
- 10.1016/j.colsurfb.2016.01.040
- ISSN
- 0927-7765
- Abstract
- Iron oxide nanoparticles have been used in a wide range of biomedical applications, including drug delivery, molecular imaging, and cellular imaging. Various surface modifications have been applied to the particles to stabilize their surface and to give them a moiety for anchoring tags and/or drug molecules. Conventional methods of delivering immunosuppressant drugs often require a high dose of drugs to ensure therapeutic effects, but this can lead to toxic side effects. In this study, we used silica-coated iron oxide nanoparticles (IOSs) for a drug delivery application in which the nanoparticles carry the minimum amount of drug required to be effective to the target cells. IOSs could be loaded with water-insoluble immunosuppressive drug molecules (MPA: mycophenolic acid) and be used as a contrast agent for MRI. We characterized the IOSs for their physicochemical properties and found their average hydrodynamic diameter and core size to be 40.5 nm and 5 nm, respectively. Following the introduction of MPA-loaded IOSs (IOS/M), we evaluated the secretion dynamics of cytokines from peripheral blood mononuclear cells stimulated with phytohemagglutinin (PHA). The results showed that IOS/M effectively inhibited the secretion of the cytokines interleukin-2 and tumor necrosis factor a, with a minimal concentration of MPA. In conclusion, IOW may have potential applications in both efficient drug delivery and MRI. (C) 2016 Elsevier B.V. All rights reserved.
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