Novel piroxicam-loaded nanospheres generated by the electrospraying technique: physicochemical characterisation and oral bioavailability evaluation
- Authors
- Mustapha, Omer; Din, Fakhar Ud; Kim, Dong Wuk; Park, Jong Hyuck; Woo, Kyu Bong; Lim, Soo-Jeong; Youn, Yu Seok; Cho, Kwan Hyung; Rashid, Rehmana; Yousaf, Abid Mehmood; Kim, Jong Oh; Yong, Chul Soon; Choi, Han-Gon
- Issue Date
- Jun-2016
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Piroxicam; nanospheres; electrospraying technique; solubility; oral bioavailability
- Citation
- JOURNAL OF MICROENCAPSULATION, v.33, no.4, pp.323 - 330
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF MICROENCAPSULATION
- Volume
- 33
- Number
- 4
- Start Page
- 323
- End Page
- 330
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/13629
- DOI
- 10.1080/02652048.2016.1185475
- ISSN
- 0265-2048
- Abstract
- To determine if a novel electrospraying technique could be applied to an oral drug delivery system for improving the solubility and oral bioavailability of poorly water-soluble piroxicam; the nanospheres were generated with drug and polyvinylpyrrolidone (PVP) using electrospraying technique; and their physicochemical properties, solubility, release and pharmacokinetics were evaluated in comparison with piroxicam powder. All nanospheres had significantly increased drug solubility and dissolution rates in comparison with the drug powder. In particular, the nanosphere composed of piroxicam and PVP at a weight ratio of 2:8 gave about 600-fold higher solubility, 15-fold higher release rate and 3-fold higher AUC in comparison to piroxicam powder, leading to significantly enhanced oral bioavailability in rats, due to the mingled effect of nanonisation along with transformation to the amorphous state. Thus, this electrospraying technique can be utilised to produce a novel oral nanosphere delivery system with enhanced solubility and oral bioavailability for poorly water-soluble piroxicam.
- Files in This Item
-
Go to Link
- Appears in
Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.