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Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation
- Authors
- Bae, Hyoung Eun; Mortensen, Jonas S.; Ribeiro, Orquidea; Du, Yang; Ehsan, Muhammad; Kobilka, Brian K.; Loland, Claus J.; Byrne, Bernadette; Chae, Pil Seok
- Issue Date
- 2016
- Publisher
- Royal Society of Chemistry
- Citation
- Chemical Communications, v.52, no.81, pp.12104 - 12107
- Indexed
- SCIE
SCOPUS
- Journal Title
- Chemical Communications
- Volume
- 52
- Number
- 81
- Start Page
- 12104
- End Page
- 12107
- ISSN
- 1359-7345
- Abstract
- A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research.
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Related Researcher
- Chae, Pil Seok
- ERICA 첨단융합대학 (ERICA 바이오나노공학전공)