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Evaluation of Metabolic Stability of Kinsenoside, an Antidiabetic Candidate, in Rat and Human Liver Microsomes
- Authors
- Rehman, Shaheed Ur; Kim, In Sook; Choi, Min Sun; Luo, Zengwei; Yao, Guangming; Xue, Yongbo; Zhang, Yonghui; Yoo, Hye Hyun
- Issue Date
- Jun-2015
- Publisher
- 사단법인 한국질량분석학회
- Keywords
- kinsenoside; stability; liver microsomes
- Citation
- Mass Spectrometry Letters, v.6, no.2, pp 48 - 51
- Pages
- 4
- Indexed
- SCOPUS
KCI
- Journal Title
- Mass Spectrometry Letters
- Volume
- 6
- Number
- 2
- Start Page
- 48
- End Page
- 51
- ISSN
- 2233-4203
2093-8950
- Abstract
- Kinsenoside is a principle bioactive compound of Anoectochilus formosanus. It exhibits various pharmacological effects such as antihyperglycemic, antioxidant, anti-inflammatory, immunostimulating, and hepatoprotective activities and has recently been developed as an antidiabetic drug candidate. In this study, as part of an in vitro pharmacokinetic study, the stability of kinsenoside in rat and human liver microsomes was evaluated. Kinsenoside was found to have good metabolic stability in both rat and human liver microsomes. These results will provide useful information for further in vivo pharmacokinetic and metabolism studies.
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Related Researcher
- Yoo, Hye Hyun
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)