Keratinocytic Vascular Endothelial Growth Factor as a Novel Biomarker for Pathological Skin Condition
- Authors
- Bae, Ok-Nam; Noh, Minsoo; Chun, Young-Jin; Jeong, Tae Cheon
- Issue Date
- Jan-2015
- Publisher
- 한국응용약물학회
- Keywords
- Vascular endothelial growth factor (VEGF); Biomarker; Keratinocytic damage; Dermal toxicity
- Citation
- Biomolecules & Therapeutics, v.23, no.1, pp.12 - 18
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Biomolecules & Therapeutics
- Volume
- 23
- Number
- 1
- Start Page
- 12
- End Page
- 18
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/19226
- DOI
- 10.4062/biomolther.2014.102
- ISSN
- 1976-9148
- Abstract
- Skin is an emerging target tissue in pharmaceutical and cosmetic science. Safety assessment for dermal toxicity is a critical step for development of topically applicable pharmaceutical agents and ingredients in cosmetics. Urgent needs exist to set up toxicity testing methods for dermal safety, and identification of novel biomarkers for pathological cutaneous alteration is highly required. Here we will discuss if vascular endothelial growth factor (VEGF) has a potential as a biomarker for dermal impairment. Experimental and clinical evidences for induction of keratinocytic VEGF under pathological conditions will be reviewed.
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