Promotion Effects of Ultra-High Molecular Weight Poly-γ-Glutamic Acid on Wound Healing
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최재철 | - |
dc.contributor.author | Hiroshi Uyama | - |
dc.contributor.author | 이철훈 | - |
dc.contributor.author | 성문희 | - |
dc.date.accessioned | 2021-06-22T21:21:38Z | - |
dc.date.available | 2021-06-22T21:21:38Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.issn | 1738-8872 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/20100 | - |
dc.description.abstract | We examined the in vivo efficacy of ultra-high molecular weight poly-γ-glutamic acid (UHMW γ-PGA) for wound healing. The wound area was measured by a ruler and documented by digital photography before the animals were sacrificed at days 8 and 16 post wounding. The areas of wounds treated with UHMW γ-PGA were significantly decreased on days 8 and 16, as compared with those receiving a control treatment, and more than 70% of the UHMW γ-PGAtreated area was repaired by day 8. Hematoxylin and eosin staining confirmed that the epidermis had regenerated in the UHMW γ-PGA-treated wounds. At 16 days post wounding, collagen pigmentation and cross-linking were increased as compared with the control groups, and greater regeneration of blood vessels had occurred in UHMW γ-PGA-treated groups. Increased levels of transforming growth factor-beta and β-catenin were also observed in skin samples collected from UHMW γ-PGA-treated animals on days 8 and 16 post incision. Taken together, these findings suggest that UHMW γ-PGA promotes wound healing in vivo. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국미생물·생명공학회 | - |
dc.title | Promotion Effects of Ultra-High Molecular Weight Poly-γ-Glutamic Acid on Wound Healing | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4014/jmb.1412.12083 | - |
dc.identifier.scopusid | 2-s2.0-84934945585 | - |
dc.identifier.wosid | 000357143100024 | - |
dc.identifier.bibliographicCitation | Journal of Microbiology and Biotechnology, v.25, no.6, pp 941 - 945 | - |
dc.citation.title | Journal of Microbiology and Biotechnology | - |
dc.citation.volume | 25 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 941 | - |
dc.citation.endPage | 945 | - |
dc.identifier.kciid | ART002005693 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | FETAL | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Ultra-high molecular weight poly-γ-glutamic acid (UHMW γ-PGA) | - |
dc.subject.keywordAuthor | wound healing | - |
dc.identifier.url | https://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.1412.12083 | - |
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