Promotion Effects of Ultra-High Molecular Weight Poly-γ-Glutamic Acid on Wound Healing
- Authors
- 최재철; Hiroshi Uyama; 이철훈; 성문희
- Issue Date
- Mar-2015
- Publisher
- 한국미생물·생명공학회
- Keywords
- Ultra-high molecular weight poly-γ-glutamic acid (UHMW γ-PGA); wound healing
- Citation
- Journal of Microbiology and Biotechnology, v.25, no.6, pp 941 - 945
- Pages
- 5
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Journal of Microbiology and Biotechnology
- Volume
- 25
- Number
- 6
- Start Page
- 941
- End Page
- 945
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/20100
- DOI
- 10.4014/jmb.1412.12083
- ISSN
- 1017-7825
1738-8872
- Abstract
- We examined the in vivo efficacy of ultra-high molecular weight poly-γ-glutamic acid (UHMW γ-PGA) for wound healing. The wound area was measured by a ruler and documented by digital photography before the animals were sacrificed at days 8 and 16 post wounding. The areas of wounds treated with UHMW γ-PGA were significantly decreased on days 8 and 16, as compared with those receiving a control treatment, and more than 70% of the UHMW γ-PGAtreated area was repaired by day 8. Hematoxylin and eosin staining confirmed that the epidermis had regenerated in the UHMW γ-PGA-treated wounds. At 16 days post wounding, collagen pigmentation and cross-linking were increased as compared with the control groups, and greater regeneration of blood vessels had occurred in UHMW γ-PGA-treated groups. Increased levels of transforming growth factor-beta and β-catenin were also observed in skin samples collected from UHMW γ-PGA-treated animals on days 8 and 16 post incision. Taken together, these findings suggest that UHMW γ-PGA promotes wound healing in vivo.
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