Graphene oxide-encoded Ag nanoshells with single-particle detection sensitivity towards cancer cell imaging based on SERRS
- Authors
- Yim, Dabin; Kang, Homan; Jeon, Su-Ji; Kim, Hye-In; Yang, Jin-Kyoung; Kang, Tae Wook; Lee, Sangyeop; Choo, Jaebum; Lee, Yoon-Sik; Kim, Jin Woong; Kim, Jong-Ho
- Issue Date
- May-2015
- Publisher
- Royal Society of Chemistry
- Keywords
- ENHANCED RAMAN-SCATTERING; NANOPARTICLE PROBES; SILVER NANOSHELLS; MOLECULE
- Citation
- The Analyst, v.140, no.10, pp.3362 - 3367
- Indexed
- SCIE
SCOPUS
- Journal Title
- The Analyst
- Volume
- 140
- Number
- 10
- Start Page
- 3362
- End Page
- 3367
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/20690
- DOI
- 10.1039/c4an02382j
- ISSN
- 0003-2654
- Abstract
- Developing ultrasensitive Raman nanoprobes is one of the emerging interests in the field of biosensing and bioimaging. Herein, we constructed a new type of surface-enhanced resonance Raman scattering nanoprobe composed of an Ag nanoshell as a surface-enhanced Raman scattering-active nanostructure, which was encapsulated with 4,7,10-trioxa-1,13-tridecanediamine-functionalized graphene oxide as an ultrasensitive Raman reporter exhibiting strong resonance Raman scattering including distinct D and G modes. The designed nanoprobe was able to produce much more intense and simpler Raman signals even at a single particle level than the Ag nanoshell bearing a well-known Raman reporter, which is beneficial for the sensitive detection of a target in a complex biological system. Finally, this ultrasensitive nanoprobe successfully demonstrated its potential for bioimaging of cancer cells using Raman spectroscopy.
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