Determination of major metabolites of MAM-2201 and JWH-122 in in vitro and in vivo studies to distinguish their intake
DC Field | Value | Language |
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dc.contributor.author | Jang, Moonhee | - |
dc.contributor.author | Shin, Ilchung | - |
dc.contributor.author | Yang, Wonkyung | - |
dc.contributor.author | Chang, Hyejin | - |
dc.contributor.author | Yoo, Hye Hyun | - |
dc.contributor.author | Lee, Jaesin | - |
dc.contributor.author | Kim, Eunmi | - |
dc.date.accessioned | 2021-06-22T22:23:06Z | - |
dc.date.available | 2021-06-22T22:23:06Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 0379-0738 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/21503 | - |
dc.description.abstract | Abuse of fluorinated synthetic cannabinoid analogs to avoid existing legal regulations has increased globally. The fluorinated JWH-122 analog, MAM-2201, was first reported in September 2012 as an ingredient in herbal mixtures in Korea. MAM-2201 is more potent than JWH-122 and a fatal intoxication case has been reported. In this study, we identified major MAM-2201 and JWH-122 metabolites from in vitro metabolism studies using human liver microsomes and compared the results with those of urine specimens from suspected MAM-2201 or JWH-122 users. MAM-2201 and JWH-122 produced common metabolites, N-5-hydroxylated, N-4-hydroxylated and carboxylated JWH-122 metabolites. Trace amounts of an N-4-hydroxylated MAM-2201 metabolite, a characteristic MAM-2201 metabolite, was detected in only a few urine specimens from MAM-2201 users. Both in vitro and in vivo studies demonstrated that N-5-hydroxylated JWH-122 metabolite was the primary metabolite of MAM-2201, whereas N-4-hydroxylated JWH-122 metabolite was predominant in JWH-122 metabolism. Based on these results, relative concentrations of N-5- and N-4-hydroxylated JWH-122 metabolites should be considered to verify MAM-2201 or JWH-122 users. (C) 2014 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier BV | - |
dc.title | Determination of major metabolites of MAM-2201 and JWH-122 in in vitro and in vivo studies to distinguish their intake | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Hyun | - |
dc.identifier.doi | 10.1016/j.forsciint.2014.08.008 | - |
dc.identifier.scopusid | 2-s2.0-84907735372 | - |
dc.identifier.wosid | 000345017000025 | - |
dc.identifier.bibliographicCitation | Forensic Science International, v.244, pp.85 - 91 | - |
dc.relation.isPartOf | Forensic Science International | - |
dc.citation.title | Forensic Science International | - |
dc.citation.volume | 244 | - |
dc.citation.startPage | 85 | - |
dc.citation.endPage | 91 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Legal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Legal | - |
dc.subject.keywordPlus | SYNTHETIC CANNABINOIDS | - |
dc.subject.keywordPlus | URINARY METABOLITES | - |
dc.subject.keywordPlus | JWH-018 | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | AM-2201 | - |
dc.subject.keywordAuthor | Synthetic cannabinoid | - |
dc.subject.keywordAuthor | JWH-122 | - |
dc.subject.keywordAuthor | MAM-2201 | - |
dc.subject.keywordAuthor | In vitro metabolism | - |
dc.subject.keywordAuthor | Urine | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0379073814003223?via%3Dihub | - |
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