Targeting of poly(L-lysine) to organs that propagate prions
DC Field | Value | Language |
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dc.contributor.author | Lee, Hye-Mi | - |
dc.contributor.author | Ryou, Chongsuk | - |
dc.date.accessioned | 2021-06-22T22:44:25Z | - |
dc.date.available | 2021-06-22T22:44:25Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2014-09 | - |
dc.identifier.issn | 0883-9115 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/21988 | - |
dc.description.abstract | Poly(l-lysine) was recently discovered to inhibit prion propagation. To develop poly(l-lysine) as a potential therapeutic for prion diseases, the understanding of in vivo poly(l-lysine) behavior is pivotal. Therefore, to determine the poly(l-lysine) distribution in mouse spleen and brain, the primary and ultimate target organs for prions, we performed non-invasive longitudinal in vivo imaging and time course on live mice and ex vivo imaging on mouse organs to confirmed poly(l-lysine) was distributed, including the brain and spleen. By studying the in vivo and ex vivo fluorescence images, characteristic patterns of poly(l-lysine) accumulation and elimination depending on different administration routes were also found. Although only a portion of the administered poly(l-lysine) appears to target the brain and spleen, the specific poly(l-lysine) level in these organs was higher than that previously reported. Furthermore, the poly(l-lysine) retention in the brain and spleen was greater than that found in other organs. These results provide valuable information about poly(l-lysine) behavior in vivo, which will be an aid in designing optimal regimens for potential application of poly(l-lysine) in anti-prion therapeutics. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SAGE Publications | - |
dc.title | Targeting of poly(L-lysine) to organs that propagate prions | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ryou, Chongsuk | - |
dc.identifier.doi | 10.1177/0883911514542898 | - |
dc.identifier.scopusid | 2-s2.0-84907557983 | - |
dc.identifier.wosid | 000342896900002 | - |
dc.identifier.bibliographicCitation | Journal of Bioactive and Compatible Polymers, v.29, no.5, pp.432 - 444 | - |
dc.relation.isPartOf | Journal of Bioactive and Compatible Polymers | - |
dc.citation.title | Journal of Bioactive and Compatible Polymers | - |
dc.citation.volume | 29 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 432 | - |
dc.citation.endPage | 444 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | POLY-L-LYSINE | - |
dc.subject.keywordPlus | MOLECULAR-WEIGHT | - |
dc.subject.keywordPlus | RAT EMBRYO | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | POLYLYSINE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | BIODISTRIBUTION | - |
dc.subject.keywordPlus | DENDRIMERS | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordAuthor | Polylysine | - |
dc.subject.keywordAuthor | targeting | - |
dc.subject.keywordAuthor | organ | - |
dc.subject.keywordAuthor | in vivo | - |
dc.subject.keywordAuthor | ex vivo | - |
dc.subject.keywordAuthor | bio-fluorescence imaging | - |
dc.identifier.url | https://journals.sagepub.com/doi/10.1177/0883911514542898 | - |
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