Targeting of poly(L-lysine) to organs that propagate prions
- Authors
- Lee, Hye-Mi; Ryou, Chongsuk
- Issue Date
- Sep-2014
- Publisher
- SAGE Publications
- Keywords
- Polylysine; targeting; organ; in vivo; ex vivo; bio-fluorescence imaging
- Citation
- Journal of Bioactive and Compatible Polymers, v.29, no.5, pp.432 - 444
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Bioactive and Compatible Polymers
- Volume
- 29
- Number
- 5
- Start Page
- 432
- End Page
- 444
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/21988
- DOI
- 10.1177/0883911514542898
- ISSN
- 0883-9115
- Abstract
- Poly(l-lysine) was recently discovered to inhibit prion propagation. To develop poly(l-lysine) as a potential therapeutic for prion diseases, the understanding of in vivo poly(l-lysine) behavior is pivotal. Therefore, to determine the poly(l-lysine) distribution in mouse spleen and brain, the primary and ultimate target organs for prions, we performed non-invasive longitudinal in vivo imaging and time course on live mice and ex vivo imaging on mouse organs to confirmed poly(l-lysine) was distributed, including the brain and spleen. By studying the in vivo and ex vivo fluorescence images, characteristic patterns of poly(l-lysine) accumulation and elimination depending on different administration routes were also found. Although only a portion of the administered poly(l-lysine) appears to target the brain and spleen, the specific poly(l-lysine) level in these organs was higher than that previously reported. Furthermore, the poly(l-lysine) retention in the brain and spleen was greater than that found in other organs. These results provide valuable information about poly(l-lysine) behavior in vivo, which will be an aid in designing optimal regimens for potential application of poly(l-lysine) in anti-prion therapeutics.
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