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Thieny/Furanyl-hydroxyphenylpropenones as Inhibitors of LPS-induced ROS and NO Production in RAW 264.7 Macrophages, and Their Structure-Activity Relationship Study
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kadayat, Tara Man | - |
| dc.contributor.author | Kim, Mi Jin | - |
| dc.contributor.author | Nam, Tae-gyu | - |
| dc.contributor.author | Park, Pil-Hoon | - |
| dc.contributor.author | Lee, Eung-Seok | - |
| dc.date.accessioned | 2021-06-22T22:45:00Z | - |
| dc.date.available | 2021-06-22T22:45:00Z | - |
| dc.date.issued | 2014-08 | - |
| dc.identifier.issn | 0253-2964 | - |
| dc.identifier.issn | 1229-5949 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/22008 | - |
| dc.description.abstract | Twelve thienyl/furanyl-hydroxyphenylpropenones were Systematically designed and synthesized, and evaluated for their inhibitory effect on LPS-induced ROS and NO production in RAW 264.7 macrophages. Compound 11 displayed the most significant inhibitory activity of LPS-induced ROS and NO production in RAW 264.7 macrophages. Structure-activity relationship study indicated that para-hydroxyphenyl moiety plays an important role for inhibitory activities on both LPS-induced ROS and NO production as well as 3-thienyl moiety on molecule. | - |
| dc.format.extent | 6 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | KOREAN CHEMICAL SOC | - |
| dc.title | Thieny/Furanyl-hydroxyphenylpropenones as Inhibitors of LPS-induced ROS and NO Production in RAW 264.7 Macrophages, and Their Structure-Activity Relationship Study | - |
| dc.type | Article | - |
| dc.publisher.location | 대한민국 | - |
| dc.identifier.doi | 10.5012/bkcs.2014.35.8.2481 | - |
| dc.identifier.scopusid | 2-s2.0-84906350868 | - |
| dc.identifier.wosid | 000340690600045 | - |
| dc.identifier.bibliographicCitation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.35, no.8, pp 2481 - 2486 | - |
| dc.citation.title | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
| dc.citation.volume | 35 | - |
| dc.citation.number | 8 | - |
| dc.citation.startPage | 2481 | - |
| dc.citation.endPage | 2486 | - |
| dc.type.docType | Article | - |
| dc.identifier.kciid | ART001897402 | - |
| dc.description.isOpenAccess | Y | - |
| dc.description.journalRegisteredClass | sci | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.description.journalRegisteredClass | kci | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
| dc.subject.keywordPlus | NITRIC-OXIDE | - |
| dc.subject.keywordPlus | SYNTHETIC CHALCONES | - |
| dc.subject.keywordPlus | OXIDATIVE STRESS | - |
| dc.subject.keywordPlus | TOPOISOMERASE-I | - |
| dc.subject.keywordPlus | CELLS | - |
| dc.subject.keywordPlus | 1-FURAN-2-YL-3-PYRIDIN-2-YL-PROPENONE | - |
| dc.subject.keywordPlus | HYDROXYCHALCONES | - |
| dc.subject.keywordPlus | CYTOTOXICITY | - |
| dc.subject.keywordPlus | PYRIDINES | - |
| dc.subject.keywordPlus | FLAVONES | - |
| dc.subject.keywordAuthor | Thieny/Furanyl-hydroxyphenylpropenones | - |
| dc.subject.keywordAuthor | LPS-induced ROS and NO | - |
| dc.subject.keywordAuthor | Inhibition | - |
| dc.subject.keywordAuthor | Structure-activity relationship study | - |
| dc.identifier.url | http://koreascience.or.kr/article/JAKO201423261321749.page | - |
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Related Researcher
- Nam, Tae gyu
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)