ATM kinase promotes both caspase-8 and caspase-9 activation during TNF-alpha-induced apoptosis of HeLa cellsopen access
- Authors
- Liu, Linhua; Yim, Hyungshin; Choi, Jae Hyuk; Kim, Seung-Tak; Jin, Yinghua; Lee, Seung Ki
- Issue Date
- Mar-2014
- Publisher
- WILEY
- Keywords
- ATM; Cdc6; TNF-alpha; Mitochondria; c-FLIP
- Citation
- FEBS LETTERS, v.588, no.6, pp.929 - 935
- Indexed
- SCIE
SCOPUS
- Journal Title
- FEBS LETTERS
- Volume
- 588
- Number
- 6
- Start Page
- 929
- End Page
- 935
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/23650
- DOI
- 10.1016/j.febslet.2014.01.050
- ISSN
- 0014-5793
- Abstract
- In this study, we show that atraxia telangiectasia mutated kinase (ATM) activity is generally upregulated by different apoptotic stimuli, i.e. TNF-alpha, TRAIL, paclitaxel, or UV. Apoptotic progression is markedly attenuated by siATM-RNA through down regulation of caspase-8 and caspase-9 in parallel with decreases in FLIP-S (short form of cellular FLICE inhibitory protein) protein levels and Bid cleavage. In addition, ATM activity is upregulated through t-Cdc6 while caspase-8 and caspase-9 activities increase. Taken together, we suggest that ATM regulates caspase-8 activation by influencing levels of FLIP-S, ATM kinase activity is upregulated by t-Cdc6, and increased ATM activity plays an essential role in the amplification of apoptosis in TNF-alpha-stimulated HeLa cells. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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