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Evaluation of stability and simultaneous determination of fimasartan and amlodipine by a HPLC method in combination tabletsopen access
- Authors
- Moon, Hyeon Woo; Yousaf, Abid Mehmood; Cho, Kwan Hyung; Yong, Chul Soon; Kim, Jong Oh; Choi, Han-Gon
- Issue Date
- Jul-2014
- Publisher
- Shenyang Pharmaceutical University
- Keywords
- Amlodipine; Combination tablet; Fimasartan; HPLC; Stability; Validation
- Citation
- Asian Journal of Pharmaceutical Sciences, v.9, no.3, pp 123 - 128
- Pages
- 6
- Indexed
- SCOPUS
- Journal Title
- Asian Journal of Pharmaceutical Sciences
- Volume
- 9
- Number
- 3
- Start Page
- 123
- End Page
- 128
- ISSN
- 1818-0876
- Abstract
- A simple, rapid, accurate, precise and robust HPLC method was developed for the simultaneous determination of fimasartan and amlodipine in tablet dosage form. Furthermore, stability of active ingredients was evaluated under normal and stress conditions. The isocratic elution was accomplished by Nucleosil C18 column (250mm×4.6mm, 5μm) at 40°C. The mobile phase consisted of acetonitrile and 0.02M monopotassium phosphate buffer (pH 2.2) in the ratio of 50:50 (v/v) was eluted at 1.0ml/min. The eluent was monitored by the UV detector for fimasartan and amlodipine at 237nm for 8min, detection time. The validation of HPLC method was carried out in accordance with the ICH guidelines. © 2014 Shenyang Pharmaceutical University.
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Related Researcher
- Choi, Han Gon
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)