Anti-inflammatory properties of a triterpenoidal glycoside from Momordica cochinchinensis in LPS-stimulated macrophages
- Authors
- Jung, Kiwon; Chin, Young-Won; Yoon, Kee Dong; Chae, Hee-Sung; Kim, Chul Young; Yoo, Hunseung; Kim, Jinwoong
- Issue Date
- Feb-2013
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- anti-inflammation; Cucurbitaceae; gypsogenin glycoside; Momordica cochichinensis; quillaic acid glycoside
- Citation
- IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, v.35, no.1, pp 8 - 14
- Pages
- 7
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
- Volume
- 35
- Number
- 1
- Start Page
- 8
- End Page
- 14
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/28873
- DOI
- 10.3109/08923973.2012.715165
- ISSN
- 0892-3973
1532-2513
- Abstract
- Two triterpenoidal saponins were isolated from the seeds of Momordica cochinchinensis Sprenger (Cucurbitaceae). Identification of chemical structures has been performed by H-1- and C-13-NMR spectroscopy and gas chromatography (GC). One of the saponins is a new gypsogenin glycoside, named as gypsogenin 3-O-beta-D-galactopyranosyl(1 -> 2)-[alpha- L-rhamnopyranosyl(1 -> 3)]-beta-D-glucuronopyranoside (compound 1), which is reported for the first time from natural resources. The other saponin is a quillaic acid glycoside (compound 2), which showed anti-inflammatory activities in RAW 264.7 cells. The mechanistic understanding of anti-inflammatory activities demonstrates that compound 2 inhibits lipopolysaccharide-induced expression of nitric oxide and IL-6 via NF-kappa B pathway.
- Files in This Item
-
Go to Link
- Appears in
Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/28873)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.