Reprogramming of cancer stem cells into non-tumorigenic cells using stem cell exosomes for cancer therapy
- Authors
- Lee, Kyoung Soo; Choi, Ji Suk; Cho, Yong Woo
- Issue Date
- May-2019
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Exosomes; Cancer stem cells; Reprogramming; Drug resistance
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.512, no.3, pp 511 - 516
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 512
- Number
- 3
- Start Page
- 511
- End Page
- 516
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/2937
- DOI
- 10.1016/j.bbrc.2019.03.072
- ISSN
- 0006-291X
1090-2104
- Abstract
- Cancer stem cells (CSCs) are a small population of cells with stem cell-like properties found in tumors. CSCs are closely associated with tumor heterogeneity, which influences tumor progress, metastasis, and drug resistance. Here, we propose a concept to enhance efficacy of cancer therapy through CSC reprogramming into non-tumorigenic cells using stem cell -derived exosomes with osteoinductive potential. We hypothesized that exosomes derived from osteogenic differentiating human adipose-derived stem cells (0D-EX0s) contain specific cargos capable of inducing osteogenic differentiation of CSCs. Quantitative RT-PCR analysis revealed that OD-EXO5 enhanced the expression of osteogenic-related genes, such as alkaline phosphatase (ALPL), osteocalcin (BGLAP), and runt-related transcription factor 2 (RUNX2). In addition, expression of drug-resistance genes such as ATP binding cassette (ABC) transporter, the breast cancer gene family (BCRA1 and BCRA2), and the ErbB gene family were significantly decreased in OD-EXO-treated CSCs. Our findings suggest that OD-EXOs function as a biochemical cue for CSC reprogramming and contribute to overcoming therapeutic resistance. (C) 2019 Elsevier Inc. All rights reserved.
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