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Copper sulfide: An emerging adaptable nanoplatform in cancer theranostics

Authors
Poudel, KishworGautam, MilanJin, Sung GiuChoi, Han-GonYong, Chul SoonKim, Jong Oh
Issue Date
May-2019
Publisher
ELSEVIER SCIENCE BV
Keywords
Copper sulfide; Nanoplatforms; Therapeutics; Theranostics
Citation
INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.562, pp.135 - 150
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume
562
Start Page
135
End Page
150
URI
https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/2951
DOI
10.1016/j.ijpharm.2019.03.043
ISSN
0378-5173
Abstract
Copper sulfide nanoparticles (CuS NPs), emerging nanoplatforms with dual diagnostic and therapeutic applications, are being actively investigated in this era of "war on cancer" owing to their versatility and adaptability. This article discusses the pros and cons of using CuS NPs in diagnostics, therapeutics, and theranostics. The first section introduces CuS NPs and discusses the features that render them more advantageous than other established nanoplatforms in cancer management. Subsequent sections include specific in vitro and in vivo results of different studies showing the potential of CuS NPs as nanoplatforms. Methods used for visualization (photoacoustic imaging and magnetic resonance imaging) of CuS NPs and treatment (phototherapy and combinatorial therapy) have also been discussed. Furthermore, the challenges and opportunities associated with using CuS NPs have been elucidated. Further investigations on CuS NPs are required to translate it for clinical applications.
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