Sublingual Administration of Bacteria-Expressed Influenza Virus Hemagglutinin 1 (HA1) Induces Protection against Infection with 2009 Pandemic H1N1 Influenza VirusSublingual Administration of Bacteria-Expressed Influenza Virus Hemagglutinin 1 (HA1) Induces Protection against Infection with 2009 Pandemic H1N1 Influenza Virus
- Other Titles
- Sublingual Administration of Bacteria-Expressed Influenza Virus Hemagglutinin 1 (HA1) Induces Protection against Infection with 2009 Pandemic H1N1 Influenza Virus
- Authors
- 심병식; 최정아; Ho-Hyun Song; 박성무; 천인수; Ji-Eun Jang; Sun Je Woo; Chung Hwan Cho; 송민석; 김혜미; Kyung Joo Song; 이재면; 김성욱; 송대섭; 최영기; 김재욱; Huan Nguyen; 김동욱; Young Yil Bahk; 윤철희; 송만기
- Issue Date
- Mar-2013
- Publisher
- 한국미생물학회
- Keywords
- Hemagglutinin; mucosal immune response; non-glycosylation; pandemic; sublingual
- Citation
- The Journal of Microbiology, v.51, no.1, pp.130 - 135
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- The Journal of Microbiology
- Volume
- 51
- Number
- 1
- Start Page
- 130
- End Page
- 135
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/30499
- DOI
- 10.1007/s12275-013-2399-z
- ISSN
- 1225-8873
- Abstract
- Influenza viruses are respiratory pathogens that continue to pose a significantly high risk of morbidity and mortality of humans worldwide. Vaccination is one of the most effective strategies for minimizing damages by influenza outbreaks. In addition, rapid development and production of efficient vaccine with convenient administration is required in case of influenza pandemic. In this study, we generated recombinant influenza virus hemagglutinin protein 1 (sHA1) of 2009 pandemic influenza virus as a vaccine candidate using a wellestablished bacterial expression system and administered it into mice via sublingual (s.l.) route. We found that s.l. immunization with the recombinant sHA1 plus cholera toxin (CT) induced mucosal antibodies as well as systemic antibodies including neutralizing Abs and provided complete protection against infection with pandemic influenza virus A/CA/04/09 (H1N1) in mice. Indeed, the protection efficacy was comparable with that induced by intramuscular (i.m.) immunization route utilized as general administration route of influenza vaccine. These results suggest that s.l. vaccination with the recombinant non-glycosylated HA1 protein offers an alternative strategy to control influenza outbreaks including pandemics.
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