Anti-inflammatory effects of dehydrogeijerin in LPS-stimulated murine macrophages
- Authors
- Bae, Deok Sung; Kim, Chul Young; Lee, Jae Kwon
- Issue Date
- Dec-2012
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Inflammation; Geijerin; Dehydrogeijerin
- Citation
- INTERNATIONAL IMMUNOPHARMACOLOGY, v.14, no.4, pp 734 - 739
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- INTERNATIONAL IMMUNOPHARMACOLOGY
- Volume
- 14
- Number
- 4
- Start Page
- 734
- End Page
- 739
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/31344
- DOI
- 10.1016/j.intimp.2012.10.009
- ISSN
- 1567-5769
1878-1705
- Abstract
- In this study, we investigated whether Heracleum (H) moellendorffii Hance-derived dehydrogeijerin and geijerin could be used to suppress lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophage cell lines. Raw 264.7 cells. Dehydrogeijerin reduced nitric oxide (NO) and inducible nitric oxide synthase (iNOS) production from LPS-stimulated Raw 264.7 cells, but on the other hand, geijerin did not reduce NO production. Dehydrogeijerin, unlike geijerin, has a double bond at C2'-C3' with an oxo function at C1'. Pre-treatment of Raw 264.7 cells with dehydrogeijerin reduced the production of cyclooxigenase-2 (COX-2) and pro-inflammatory cytokines. These inhibitory effects were associated with decreases in the phosphorylation of mitogen-activated protein (MAP) kinases. Our results indicate that dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that dehydrogeijerin could be a potential candidate for the treatment of inflammatory disease. (c) 2012 Elsevier B.V. All rights reserved.
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