Dibenzocyclooctadiene lignans, gomisins J and N inhibit the Wnt/beta-catenin signaling pathway in HCT116 cells
DC Field | Value | Language |
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dc.contributor.author | Kang, Kyungsu | - |
dc.contributor.author | Lee, Kyung-Mi | - |
dc.contributor.author | Yoo, Ji-Hye | - |
dc.contributor.author | Lee, Hee Ju | - |
dc.contributor.author | Kim, Chul Young | - |
dc.contributor.author | Nho, Chu Won | - |
dc.date.accessioned | 2021-06-23T06:04:11Z | - |
dc.date.available | 2021-06-23T06:04:11Z | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/31349 | - |
dc.description.abstract | Here, we report that gomisin J and gomisin N. clibenzocyclooctadiene type lignans isolated from Sch (sonchinensis, inhibit Wnt/beta-catenin signaling in HCT116 cells. Gomisins J and N appear to inhibit Wnt/Bcatenin signaling by disrupting the interaction between beta-catenin and its specific target DNA sequences (TCF binding elements, TBE) rather than by altering the expression of the beta-catenin protein. Gomisins J and N inhibit HCT116 cell proliferation by arresting the cell cycle at the G0/G1 phase. The G0/G1 phase arrest induced by gomisins J and N appears to be caused by a decrease in the expression of Cyclin D1, a representative target gene of the Wnt/beta-catenin signaling pathway, as well as Cdk2, Cdk4, and E2F-1. Therefore, gomisins J and N, the novel Wnt/beta-catenin inhibitors discovered in this study, may serve as potential agents for the prevention and treatment of human colorectal cancers. (C) 2012 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Dibenzocyclooctadiene lignans, gomisins J and N inhibit the Wnt/beta-catenin signaling pathway in HCT116 cells | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.bbrc.2012.10.046 | - |
dc.identifier.scopusid | 2-s2.0-84869204968 | - |
dc.identifier.wosid | 000312431900014 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.428, no.2, pp 285 - 291 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 428 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 285 | - |
dc.citation.endPage | 291 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | COLON-CANCER CELLS | - |
dc.subject.keywordPlus | SCHISANDRA-CHINENSIS | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | SUPPRESSES GROWTH | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | COMPONENTS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordAuthor | Wnt/beta-catenin | - |
dc.subject.keywordAuthor | Cancer chemoprevention | - |
dc.subject.keywordAuthor | Dibenzocyclooctadiene lignan | - |
dc.subject.keywordAuthor | Schisandra chinensis | - |
dc.subject.keywordAuthor | Gomisin | - |
dc.subject.keywordAuthor | Cyclin D1 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0006291X12019833?via%3Dihub | - |
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