Dibenzocyclooctadiene lignans, gomisins J and N inhibit the Wnt/beta-catenin signaling pathway in HCT116 cells
- Authors
- Kang, Kyungsu; Lee, Kyung-Mi; Yoo, Ji-Hye; Lee, Hee Ju; Kim, Chul Young; Nho, Chu Won
- Issue Date
- Nov-2012
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Wnt/beta-catenin; Cancer chemoprevention; Dibenzocyclooctadiene lignan; Schisandra chinensis; Gomisin; Cyclin D1
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.428, no.2, pp 285 - 291
- Pages
- 7
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 428
- Number
- 2
- Start Page
- 285
- End Page
- 291
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/31349
- DOI
- 10.1016/j.bbrc.2012.10.046
- ISSN
- 0006-291X
1090-2104
- Abstract
- Here, we report that gomisin J and gomisin N. clibenzocyclooctadiene type lignans isolated from Sch (sonchinensis, inhibit Wnt/beta-catenin signaling in HCT116 cells. Gomisins J and N appear to inhibit Wnt/Bcatenin signaling by disrupting the interaction between beta-catenin and its specific target DNA sequences (TCF binding elements, TBE) rather than by altering the expression of the beta-catenin protein. Gomisins J and N inhibit HCT116 cell proliferation by arresting the cell cycle at the G0/G1 phase. The G0/G1 phase arrest induced by gomisins J and N appears to be caused by a decrease in the expression of Cyclin D1, a representative target gene of the Wnt/beta-catenin signaling pathway, as well as Cdk2, Cdk4, and E2F-1. Therefore, gomisins J and N, the novel Wnt/beta-catenin inhibitors discovered in this study, may serve as potential agents for the prevention and treatment of human colorectal cancers. (C) 2012 Elsevier Inc. All rights reserved.
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