Effects of Noscarna (TM) on hypertrophic scarring in the rabbit ear model: Histopathological aspects

Abstract

In this study, we evaluated the effects of silicone-based gel on the healing of hypertrophic scars in the rabbit ear model. After 4-week application of silicone-based gel containing allantoin, dexpanthenol and heparin (Noscarna (TM)) to scars in a rabbit ear model of hypertrophic scarring, significant improvements in hypertrophic scar healing and a great loss of skin pigment were observed compared to the non-treated control, base or silicone control-treated scars. Furthermore, histological analysis of Noscarna (TM)-treated scars revealed a significant reduction in scar elevation index (SEI), anterior skin and epithelial thicknesses, inflammatory cells, vessels, collagen disorganization and fibroblasts compared to all control hypertrophic scars. Furthermore, Noscarna (TM) showed more favorable effects on hypertrophic scars than a commercial product, ContractubexA (R). Therefore, these results clearly demonstrated that the newly developed silicone-based gel, Noscarna (TM), could be a promising formulation as an effective therapeutic agent for hypertrophic scars.