Cyclooxygenase inhibitory activity of ginsenosides from heat-processed ginseng
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, Hye Hyun | - |
dc.contributor.author | Park, Jeong Hill | - |
dc.date.accessioned | 2021-06-23T06:53:47Z | - |
dc.date.available | 2021-06-23T06:53:47Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 0308-8146 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/32204 | - |
dc.description.abstract | Ginsenosides, from heat-processed ginseng, and sapogenins were evaluated for their inhibitory effects on the enzyme catalytic activities of cyclooxygenases-1 and -2 (COX-1 and -2). The ginsenosides, 20(S)-Rg(3), Rg(5), and Rk(1), inhibited COX-2 activity, but did not affect the enzyme activity of COX-1. Protopanaxatriol (PPT) moderately inhibited both COX-1 and -2. The ginsenosides, 20(R)-Rg(3), Re, and protopanaxadiol (PPD) showed a minimal effect on COX-1 and -2 activities. Taken together, ginsenosides Rg(3) (20S-form), Rg(5) and Rk(1) showed selective inhibitory activity on COX-2 by behaving as an inhibitor of the enzyme-substrate reaction. (C) 2012 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier BV | - |
dc.title | Cyclooxygenase inhibitory activity of ginsenosides from heat-processed ginseng | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Hyun | - |
dc.identifier.doi | 10.1016/j.foodchem.2012.01.081 | - |
dc.identifier.scopusid | 2-s2.0-84862829619 | - |
dc.identifier.wosid | 000302986400051 | - |
dc.identifier.bibliographicCitation | Food Chemistry, v.133, no.3, pp.998 - 1000 | - |
dc.relation.isPartOf | Food Chemistry | - |
dc.citation.title | Food Chemistry | - |
dc.citation.volume | 133 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 998 | - |
dc.citation.endPage | 1000 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CARCINOGENESIS | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | RG3 | - |
dc.subject.keywordAuthor | Heat-processed ginseng | - |
dc.subject.keywordAuthor | Ginsenoside | - |
dc.subject.keywordAuthor | Cyclooxygenase-1 | - |
dc.subject.keywordAuthor | Cyclooxygenase-2 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0308814612001331?via%3Dihub | - |
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