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Cyclooxygenase inhibitory activity of ginsenosides from heat-processed ginseng
- Authors
- Yoo, Hye Hyun; Park, Jeong Hill
- Issue Date
- Aug-2012
- Publisher
- Elsevier BV
- Keywords
- Heat-processed ginseng; Ginsenoside; Cyclooxygenase-1; Cyclooxygenase-2
- Citation
- Food Chemistry, v.133, no.3, pp.998 - 1000
- Indexed
- SCIE
SCOPUS
- Journal Title
- Food Chemistry
- Volume
- 133
- Number
- 3
- Start Page
- 998
- End Page
- 1000
- ISSN
- 0308-8146
- Abstract
- Ginsenosides, from heat-processed ginseng, and sapogenins were evaluated for their inhibitory effects on the enzyme catalytic activities of cyclooxygenases-1 and -2 (COX-1 and -2). The ginsenosides, 20(S)-Rg(3), Rg(5), and Rk(1), inhibited COX-2 activity, but did not affect the enzyme activity of COX-1. Protopanaxatriol (PPT) moderately inhibited both COX-1 and -2. The ginsenosides, 20(R)-Rg(3), Re, and protopanaxadiol (PPD) showed a minimal effect on COX-1 and -2 activities. Taken together, ginsenosides Rg(3) (20S-form), Rg(5) and Rk(1) showed selective inhibitory activity on COX-2 by behaving as an inhibitor of the enzyme-substrate reaction. (C) 2012 Elsevier Ltd. All rights reserved.
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Related Researcher
- Yoo, Hye Hyun
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)