Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
New diarylureas and diarylamides possessing acet(benz)amidophenyl scaffold: Design, synthesis, and antiproliferative activity against melanoma cell line
- Authors
- Kim, Hee Jin; Cho, Hye Jung; Kim, Hwan; El-Gamal, Mohammed I.; Oh, Chang-Hyun; Lee, So Ha; Sim, Taebo; Hah, Jung-Mi; Yoo, Kyung Ho
- Issue Date
- May-2012
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Melanoma; Antiproliferative activity; Acet(benz)amidophenyl; Diarylurea; Diarylamide; A375P
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.9, pp.3269 - 3273
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 22
- Number
- 9
- Start Page
- 3269
- End Page
- 3273
- ISSN
- 0960-894X
- Abstract
- A series of new diarylurea and diarylamide derivatives possessing acet(benz)amidophenyl scaffold was synthesized. Their in vitro antiproliferative activity was tested against A375P human melanoma cell line. Compounds 1c,d and 2c,d showed the highest potencies with IC50 values in sub-micromolar scale. In addition, compounds 1b,e,l and 2e,l were more potent than Sorafenib but with IC50 values in micromolar range. Moreover, compound 2c was equipotent to Vemurafenib, and 2d showed higher potency than Vemurafenib against A375P. Molar refractometry calculation and ADME profiling of the highest potent four derivatives 1c,d and 2c,d are also reported. (C) 2012 Elsevier Ltd. All rights reserved.
- Files in This Item
- Go to Link
- Appears in
Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Hah, Jung Mi
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)