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Alterations in differentially expressed genes by exposure to a mixture of carcinogenic polycyclic aromatic hydrocarbons in the liver of Oryzias latipes
- Authors
- Oh, Jeong Hwan; Moon, Hyo-Bang; Choe, Eun Sang
- Issue Date
- May-2012
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- BaP; cPAH; Cytochrome P450; Medaka
- Citation
- ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v.33, no.3, pp 403 - 407
- Pages
- 5
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Volume
- 33
- Number
- 3
- Start Page
- 403
- End Page
- 407
- ISSN
- 1382-6689
1872-7077
- Abstract
- The effects of a mixture of carcinogenic polycyclic aromatic hydrocarbons (cPAHs) on transcriptional responses in the liver of medaka, Oryzias latipes, were investigated by identifying differentially expressed genes (DEGs). Five DEGs were identified as cytochrome P450 2P1 (CYP450 2P1), malate dehydrogenase, anti-thrombin III, NADH dehydrogenase subunit 4, and transferrin. These DEGs were quantified by real-time polymerase chain reaction. Only CYP450 2P1 mRNA was found to be upregulated by exposure to cPAHs mixture, suggesting that CYP450 2P1 mRNA can be a potential marker for prediction of the biological effects of a mixture of cPAHs on fish. (C) 2012 Elsevier B.V. All rights reserved.
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Related Researcher
- Moon, Hyo-Bang
- ERICA 공학대학 (ERICA 해양융합공학과)