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Preparation of Neutron-Activatable Holmium Nanoparticles for the Treatment of Ovarian Cancer Metastases
- Authors
- Di Pasqua, Anthony J.; Huckle, James E.; Kim, Jin-Ki; Chung, Younjee; Wang, Andrew Z.; Jay, Michael; Lu, Xiuling
- Issue Date
- Apr-2012
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- drug delivery; holmium; imaging; nanoparticle; ovarian cancer
- Citation
- SMALL, v.8, no.7, pp.997 - 1000
- Indexed
- SCIE
SCOPUS
- Journal Title
- SMALL
- Volume
- 8
- Number
- 7
- Start Page
- 997
- End Page
- 1000
- ISSN
- 1613-6810
- Abstract
- Nanoparticles containing stable holmium (165Ho) are prepared by nanotemplate engineering and subsequently irradiated in a neutron flux to yield 166Ho, a beta-emitting radiotherapeutic isotope. After intraperitoneal injection to mice bearing SKOV-3 ovarian tumors, significant tumor accumulation of the 166Ho-nanoparticles is observed by SPECT imaging indicating the potential of these neutron activatable nanoparticles for internal radiation therapy of ovarian cancer metastases.
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Related Researcher
- Kim, Jin-Ki
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)