Development of novel ibuprofen-loaded solid dispersion with enhanced bioavailability using cycloamylose
- Authors
- Baek, Hyung Hee; Kim, Dae-Hwan; Kwon, So Young; Rho, Shin-Joung; Kim, Dong-Wuk; Choi, Han-Gon; Kim, Yong-Ro; Yong, Chul Soon
- Issue Date
- Mar-2012
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Bioavailability; Cycloamylose; Ibuprofen; Solid dispersion
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.35, no.4, pp.683 - 689
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 35
- Number
- 4
- Start Page
- 683
- End Page
- 689
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/33182
- DOI
- 10.1007/s12272-012-0412-4
- ISSN
- 0253-6269
- Abstract
- To develop a novel ibuprofen-loaded solid dispersion with enhanced bioavailability using cycloamylose, it was prepared using spray-drying techniques with cycloamylose at a weight ratio of 1:1. The effect of cycloamylose on aqueous solubility of ibuprofen was investigated. The physicochemical properties of solid dispersions were investigated using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction. The dissolution and bioavailability in rats were evaluated compared with ibuprofen powder. This ibuprofen-loaded solid dispersion improved about 14-fold drug solubility. Ibuprofen was present in an unchanged crystalline state, and cycloamylose played the simple role of a solubilizing agent in this solid dispersion. Moreover, the dispersion gave 2-fold higher AUC (area under the drug concentration-time curve) value compared with a ibuprofen powder, indicating that it improved the oral bioavailability of ibuprofen in rats. Thus, the solid dispersion may be useful to deliver ibuprofen with enhanced bioavailability without crystalline change.
- Files in This Item
-
Go to Link
- Appears in
Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/33182)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.